Muhammad Medical College is located just outside Mirpurkhas (6 km from Zero point) on Hyderabad road. This is opposite Ratanabad Railway station near main bus stand. It spreads over 40 acres owned by Muhammad Foundation Trust for its projects. All necessary facilities including building, gas, electricity, telephone, e-mail. Internet, transport, accommodation, food and drink spots are available. Public transport operating along Hyderabad road provides frequent and regular access to the college.

The college building is more than sufficient to the requirement and has all the necessary departments. Each department has its own museum, laboratory and tutorial room, which are well equipped and fascinating. All facilities are modern and up-to the mark. Students get clinical training in nearby 500 bedded Muhammad Medical college Hospital. There are hostels for boys and girls onsite and in the city. A new large state of art 3 stories girls' hostel has just been established onsite.