As in Khyber Pakhtunkhwa there was a great need to have a medical college for girls. Such facility already exists in Punjab in the name of Fatima Jinnah Medical College Lahore and in Sind Province People Medical College Nawabshah where only female students are admitted. The Government of Khyber Pakhtunkhwa took policy decision in this regard and in August 2003, the Provincial Cabinet approved the establishment of a separate Girls Campus of Khyber Medical College Peshawar.
The Girls Campus of KMC Peshawar started functioning in PDA Building, Block-IV, Phase-V, Hayatabad and admitted first batch of 50 students during the academic session 2004-05. This institution admitted 2nd batch of 50 students of First Year MBBS during academic session 2005-06. The then Chief Minister of Khyber Pakhtunkhwa Mr. Akram Khan Durani announced the Girls Campus of KMC Peshawar as an independent "Khyber Girls Medical College" w.e.f 8th December 2005. Hayatabad Medical Complex is its teaching hospital. The Provincial Government has approved creation of 159 posts of teaching and Para-medical staff to fulfill the staff requirements of Khyber Girls Medical College. Recruitment of KGMC's own teachers is completed through NWFP Public Service Commission. The college is recognized by PM & DC Vide Letter No. PF-7-E-2008(Council)/108573, dated 26th December 2008, and vide Notification No. F.3-46/2008-MER, dated 17th January 2009.
The Department of Anatomy Biochemistry, Physiology, Pharmacology, Pathology, Forensic Medicine and Community Medicine have been established with well equipped laboratories, Lecture theatres, Dissection Hall, and museums. Self Learning Resource Center (SLRC) and a Library for staff and students with sufficient number of latest books, reference books and journals.
Professor Dr. Zia-Ul-Islam was the first Principal of Khyber Girls Medical College Peshawar.The present principal and Dean of the college is Professor Dr. Abid Hussain.