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"Biomaterials
save lives, relieve suffering and improve the quality
of life for a large number of patients every year." |
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Biomedical Material Sciences involve customisation
of materials for medical applications. Examples of these applications
include artificial skin, vascular and cardiovascular implants
and devices, bone graft substitutes, new prosthetic devices,
dental materials etc. Application in this field have been
rapidly expanding, due to the imagination of biomedical material
scientists and them identifying appropriate applications in
consultation with the clinicians, resulting in interdisciplinary
research collaborations.
Recently, materials used in medicine (biomaterials) have made
enormous impact on the repair and replacement of injured and
diseased part of the human body and the field is growing at
a rapid pace.
Uses of Biomaterials increased rapidly in the late 1800s,
particularly after the advent of aseptic techniques by Dr.
Joseph Lister in 1860s. The first metal devices to fix bone
fracture were used early in nineteenth century. Total hip
replacement prosthesis was implanted in 1938. In 1940s, many
surgical specialties were transformed by the introduction
of implantable medical devices, and patients benefited from
the newly developed absorbable sutures. The devices were,
however, fabricated from only a small list of metals, polymers,
and ceramics.
During the 1960s, a wide range of novel materials were developed
both for medical and non-medical applications, as a number
of newly developed materials showed promise for the production
of medical devices. This was only possible due to the imagination
of the biomaterial scientists and their understanding of the
material properties. During 1970s to 1990s, a number of new
synthetic absorbable and non-absorbable polymers; biologically-derived
materials, bio-derived macromolecules, coatings and tissue
adhesives for a myriad of clinical applications were introduced.
This was the era, when the field of biomedical materials was
truly established. The applications included blood-contacting
devices and implants, soft tissue devices for repair and soft
tissue reconstruction, dental materials, orthopedic devices
to aid bone repair and replace damaged bone and joints, and
wound dressings for large area damage to skin from trauma,
ulcers and burns. By the turn of the 21st century, the explosion
of biomedical materials was clear; this explosion was coming
in the use of absorbable biomaterials for the fabrication
of scaffolds for the synthesis of tissue in vitro
(tissue engineering) and as implants to facilitate the regeneration
of tissue in vivo (regenerative medicine).
While the implementation of some of the biomedical materials
may be for medical reasons such as the replacement of diseased
tissues required to extend life expectancies, other reasons
may include purely aesthetic ones including breast implants.
This increasing demand arises from an ageing population with
higher quality of life expectations. The biomaterial scientists
are producing new and improved implantable materials and techniques
to meet this demand, but also to aid the treatment of younger
patients where the necessary properties are even more demanding.
A counter force to this technological push is the increasing
level of regulation and the threat of litigation. To meet
these conflicting needs it is necessary to have reliable methods
of characterisation of the material and material/host tissue
interactions. In a Muslim country like Pakistan, it is always
imperative to select a biomaterial from halal sources. This
increases the importance of research and development to devise
novel methods of biomedical material technology in Pakistan.
Millions of lives have been saved by Biomedical Materials
and the quality of life for millions more is improved every
year. Still many unanswered questions regarding the biological
response to biomaterials and the optimal role of biomaterials
in tissue regeneration, continue to motivate biomaterial research
and new product development. It has become multi billion dollar
industry, creating millions of jobs. Pakistan is one of the
leading producers of surgical instruments (Sialkot) and yet
there is no research being undertaken in Pakistan in the field
of biomedical materials. Both universities and industries
in Pakistan should take a leading role in the production of
biomedical materials. In addition to hundreds and thousands
of patients needing routine replacement surgeries, the recent
earth quake in northern Pakistan, where thousands have lost
their limbs, has further emphasized the importance of this
type of research and development in Pakistan.
COMSATS Institute of Information Technology (CIIT), Lahore
has established an educational and research Institute to produce
professionals to fulfill these needs. This centre of excellence
is inherent by multi-disciplinarily in nature and has the
ability to respond to new developments that cut across subject
boundaries so as to translate fundamental research into clinical
use.
Our aim is to use our knowledge of materials and apply it
for the benefits of patients, by involving scientists, engineers
and clinicians, demonstrating the added value of the Interdisciplinary
Research Centre (IRC) in Biomedical Materials mode of support.
In future, The IRC shall be developed into a national focus
to develop implants for national needs.
These needs can only be met if we start from the basics and
equip our youngsters with this knowledge. To fulfill these
national needs a Department of Biomedical Material Sciences
has established at CIIT, as part of an Interdisciplinary Research
Centre where classes at undergraduate and graduate level are
scheduled to start early next year, thus providing students
an opportunity to work in this new and exciting field in Pakistan.
We urge our youngsters to become part of our vision, which
is to have the ability to translate fundamental research to
clinical care for the benefit of the Nation; our prospective
students will be part of this initiative and will master the
art of servicing the Nation, through education and research.
Once we have established the know how, the Department of Biomedical
Material Sciences (IRC) will be well placed to produce graduates
to respond to the national needs for an optimised biomaterials
base in the delivery of healthcare by producing biomedical
implants (spare parts) for the human body.
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